publications
Top-cited peer-reviewed manuscripts showcase groundbreaking advancements in structural biology, medicinal chemistry, and immunology. They highlight my expertise in designing key experiments, solving complex biological problems, and mentoring teams. Covering topics like drug discovery, protein stability, and vaccine design, these studies reflect global collaboration and drive innovation across disciplines.
Top Posts
- Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor
- Protein stability: a crystallographer’s perspective
Validation of Protein–Ligand Crystal Structure Models: Small Molecule and Peptide Ligands
- Crystal structure of a soluble cleaved HIV-1 envelope trimer
- Structure–function analysis of the extended conformation of a polyketide synthase module
- KRAS Inhibitors: Development of novel inhibitors targeting KRAS G12D mutations—key breakthroughs in cancer therapy
- Drug Discovery Innovations: Research on inhibitors for CDK2 and FGFR2/3 proteins for new therapeutics for rare disease
- Novel structural Insights: Contributions to polyketide synthase functionality provide critical knowledge applicable to AI-driven enzyme modeling
- HIV Vaccine Design: Research on gp120 glycans addresses immune vulnerabilities—a testament to collaborative problem-solving
Crystal structure of a two-subunit TrkA octameric gating ring assembly
Crystal structure of a two-subunit TrkA octameric gating ring assembly
Approaches to automated protein crystal harvesting
Approaches to automated protein crystal harvesting Link to Paper Precision
Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33
Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site