Revolutionizing Drug Discovery: LatentX and the Future of Protein Binder Design
Revolutionizing Drug Discovery: LatentX and the Future of Protein Binder Design LatentX generates lab-functional protein binders with picomolar affinities and near-perfect hit rates. The model co-samples protein sequence and 3D structure simultaneously for faster, more accurate design. LatentX creates novel molecules beyond nature’s repertoire, enabling new therapeutic modalities. A no-code web platform enables widespread access […]
Unveiling FragLites: Pioneering Precision in Drug Discovery
Unveiling FragLites: Pioneering Precision in Drug Discovery FragLites are a focused library of 31 halogenated fragments used to map protein binding sites with high sensitivity and specificity. They enable identification of known and novel protein interaction hotspots, aiding drug discovery and protein biology. Application on CDK2-cyclin A and bromodomain proteins (BRD4, ATAD2) validates their versatility […]
The LockTac Revolution: Binding the Future of Therapeutics
The LockTac Revolution: Binding the Future of Therapeutics LOCKTACs stabilize, rather than disrupt, natural biomolecular interactions. They offer therapeutic avenues for tackling previously intractable drug targets. By reinforcing the molecular ‘ties’ between proteins, they can amplify or inhibit signaling pathways. The 2025 Science review outlines both amplifying and inhibitory LOCKTAC examples and mechanisms. Current research […]
The Shape-Shifting World of Intrinsically Disordered Region Binding Proteins
The Shape-Shifting World of Intrinsically Disordered Region Binding Proteins IDRs lack stable structures, making them historically difficult to target. New computational strategies enable design of binders that match IDR flexibility. Deep learning models and AI drive rapid identification of selective binders. Designed proteins achieve picomolar-to-nanomolar binding affinities. Applications span disease intervention, diagnostics, and cellular signaling […]
Unlocking Protein Structure Insights without a Lab: Harnessing CRO Services for Structural Biology Research
Unlocking Protein Structure Insights without a Lab: Harnessing CRO Services for Structural Biology Research CRO partnerships: eliminate the need for costly internal lab infrastructure exceeding $5M for protein structure work. Full protein structure workflows: available from cloning, expression, purification, through crystallization and data collection. Protein purification: uses chromatographic techniques and quality control like SDS-PAGE and […]
Engineering the Future of Proteins: Unveiling the Latest AI Tools Transforming Structural Biology in 2025
Engineering the Future of Proteins: Unveiling the Latest AI Tools Transforming Structural Biology in 2025 AlphaFold 3 refines bound-state predictions for drug discovery by modeling protein–ligand interactions at sub-angstrom accuracy. OpenFold 3 offers an open-source, public-data implementation of AlphaFold 3 for transparent benchmarking and academic use. RFdiffusion leverages diffusion processes on RoseTTAFold to generate novel […]
Unleashing Dynamic Precision: How DRGSCROLL Transforms Protein–Ligand Docking
Unleashing Dynamic Precision: How DRGSCROLL Transforms Protein–Ligand Docking Evolutionary side-chain optimization reveals true binding interactions. Automated rotamer search eliminates manual pre-selection steps. Enhances affinity and specificity predictions in lead optimization. Validates docking hypotheses across protein–protein and allosteric interfaces. Improves local geometry for cryo-EM model fitting. Exports refined complexes for molecular dynamics and free-energy calculations. Upcoming […]
Capturing the Invisible: Understanding the Ångström in Structural Biology
Capturing the Invisible: Understanding the Ångström in Structural Biology The ångström equals 1 × 10⁻¹⁰ m, ideal for atomic and molecular dimensions. Named after Anders Jonas Ångström, pioneer of solar spectroscopy. Core to X-ray crystallography, NMR, and cryo-EM in structural biology. Enables mapping of atomic coordinates and bond geometries with sub-Å accuracy. Persistence due to […]
Revolutionizing Protein Structure Determination: How MICA Combines Cryo-EM and AlphaFold3 for Unprecedented Accuracy
Revolutionizing Protein Structure Determination: How MICA Combines Cryo-EM and AlphaFold3 for Unprecedented Accuracy Revolutionary Integration: MICA combines cryo-EM experimental data with AlphaFold3 predictions through multimodal deep learning, achieving unprecedented accuracy in automated protein structure determination Outstanding Performance: Achieved average TM-score of 0.93 on high-resolution maps, outperforming state-of-the-art methods ModelAngelo and EModelX by significant margins Robust […]
Engineering Protein Stability: Unlocking the Secrets of Successful Crystallization
Engineering Protein Stability: Unlocking the Secrets of Successful Crystallization Modern construct design leverages computational tools like AlphaFold3 and specialized servers to systematically remove flexible regions while preserving functional domains Temperature optimization and codon usage correction dramatically improve expression levels and protein solubility in heterologous systems Expression system selection has become more sophisticated, with cell-free systems […]