The Invisible Invasion: How Microscopic Plastics Are Infiltrating Human Organ Systems
The Invisible Invasion: How Microscopic Plastics Are Infiltrating Human Organ Systems The potential impacts of micro-and-nano plastics on various organ systems in humans Cardiovascular Threat: Microplastics accumulate in arterial plaques, increasing major adverse cardiovascular event risk by 4.5-fold Neurological Disruption: Nanoplastics cross blood-brain barriers, disrupting mitochondrial energy production essential for cognitive function Renal Dysfunction: Plastic […]
The 79th Organ: When Art and Biology Meet Bioengineering in the Fight Against Microplastics
The 79th Organ: When Art and Biology Meet Bioengineering in the Fight Against Microplastics Art project imagines 79th organ to extract microplastics from human body Anatomical Evolution: Human organ count continues expanding with recent discoveries of mesentery, interstitium, and tubarial glands establishing precedent for new organ classifications Microplastic Crisis: Humans ingest credit card equivalent plastic […]
Spacial Score─A Comprehensive Topological Indicator for Small-Molecule Complexity
Spacial Score─A Comprehensive Topological Indicator for Small-Molecule Complexity Spacial Score─A Comprehensive Topological Indicator for Small-Molecule Complexity Optimal Range: Compounds with nSPS between 20 and 40 show the highest potency and selectivity Granular Metric: SPS integrates hybridization, stereogenicity, ring systems, and branching per atom Size Normalization: Dividing SPS by heavy‐atom count yields nSPS for fair comparisons […]
The $40 Billion Revolution: How Bispecific Antibodies Are Transforming Cancer Care
The $40 Billion Revolution: How Bispecific Antibodies Are Transforming Cancer Care The $40 Billion Race: Bispecific Antibodies Are Redefining Cancer Therapy Market Transformation: Bispecific antibody market projected to reach $40-484 billion by 2034, representing 44% annual growth from current $12-17 billion valuation Clinical Breakthrough: Over 70% response rates achieved in heavily pretreated multiple myeloma patients […]
Revolutionizing Protein Crystallography: The Synergy of TELSAM-DARPin Fusion and Electric Field Optimization
Revolutionizing Protein Crystallography: The Synergy of TELSAM-DARPin Fusion and Electric Field Optimization Engineering Protein Linkers for Optimized TELSAM-DARPin Fusion and Crystallization With Electric Field-Based Polymer Orientation Rapid Formation: Short semi-flexible linkers enable crystal formation within 24 hours, dramatically reducing typical crystallization timelines from weeks to days Ultra-low Concentrations: TELSAM fusions crystallize at 0.1 mg/mL, enabling […]
The Memorization Trap: Have Protein-Ligand Cofolding Methods Transcended Simple Data Recall?
The Memorization Trap: Have Protein-Ligand Cofolding Methods Transcended Simple Data Recall? Have protein-ligand cofolding methods moved beyond memorisation? Memorization Over Understanding: Current cofolding methods largely memorize ligand poses from training data, limiting de novo drug design applications Performance Degradation: Models show substantial accuracy drops when evaluated on protein-ligand combinations significantly different from training sets Binding […]
Remapping the Chemical and Pharmacological Spaces of Drugs: Navigating Tomorrow’s Therapeutic Frontier
Remapping the Chemical and Pharmacological Spaces of Drugs: Navigating Tomorrow’s Therapeutic Frontier Remapping the Chemical Space and the Pharmacological Space of Drugs: What Can We Expect from the Road Ahead? Data-Driven Maps: Interactive AI-powered visualizations transform vast molecular libraries into navigable landscapes. Non-Linear Embeddings: UMAP and GTM outperform PCA for preserving local and global structures […]
Revolutionary Cryo-EM Breakthrough: Di-Gembodies Transform Small Protein Structure Determination
Revolutionary Cryo-EM Breakthrough: Di-Gembodies Transform Small Protein Structure Determination Di-Gembodies Size Barrier Elimination: Di-Gembodies enable cryo-EM structure determination of proteins as small as 14 kDa, breaking through the traditional ~50 kDa limitation that excluded 75% of human proteins Parallel Structure Solutions: Revolutionary capability to simultaneously determine structures of two different proteins within a single cryo-EM […]
From Waste to Wonder: How Bacteria Transform Plastic into Life-Saving Medicine
From Waste to Wonder: How Bacteria Transform Plastic into Life-Saving Medicine Researchers turn plastic into paracetamol Circular Economy Integration: Plastic waste becomes pharmaceutical feedstock, demonstrating true circular economy principles in healthcare manufacturing where 300 million tons of pharmaceutical plastic waste annually could be transformed into essential medicines. Zero-Carbon Synthesis: Room temperature bacterial fermentation produces paracetamol […]
Genomic Giants: The Lungfish That Rewrote DNA Records
Genomic Giants: The Lungfish That Rewrote DNA Records Big fish! Genomic Scale: Lepidosiren paradoxa possesses 91 billion DNA bases, establishing the largest animal genome record Expansion Rate: The genome adds one human genome equivalent every 10 million years through transposable element proliferation Regulatory Breakdown: Loss of piRNA and KRAB-ZFP suppression systems enabled unchecked transposable element […]